major route of transmission is through blood inoculation, with intravenous drug use accounting for over 40% of cases, Transmission via blood products is now fortunately rare
HCV infection has a much higher rate than HBV of progression to chronic disease and eventual cirrhosis
In persistent infection, circulating HCV-RNA is detectable
the high mortality rate among pregnant women, approaching 20%
Virus can be detected in stools, and anti-HEV IgG and IgM antibodies are detectable in serum.