Wednesday, December 8, 2010

What is Gout ?

A disorder of uric acid crystals deposition in joints
Primary Gout (90% of cases)

Enzyme defects unknown (85%–90% of primary gout): Overproduction of uric acid
Underexcretion of uric acid with normal production

Secondary Gout (10% of cases)

Associated with increased nucleic acid turnover—e.g., leukemias and tumor lysis syndrome
Chronic renal disease: Reduced excretion of uric acid
Inborn errors of metabolism—e.g., complete HGPRT

Hypoxanthine-guanine phosphoribosyltransferase deficiency (Lesch-Nyhan syndrome).

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