Friday, January 7, 2011

BURKITT’S LYMPHOMA.

Starry Sky pattern

It is a fast growing tumor
Three types are seen
AFRICAN (ENDEMIC)
SPORADIC (EPIDEMIC)
AGGRESSIVE LYMPHOMA seen in HIV patients
MEDIUM SIZED CELLS with HIGH MITOTIC RATE & APOPTOTIC TUMOR CELL DEATH
Associated with EBV infection
Creates a STARRY SKY pattern in lymph nodes
Most tumors manifest at EXTRA NODAL site
African type starts from Jaw or Face
Other types starts from Abdomen
It can also start from Ovaries & Testes
Can progress to ALL which is then reffered to as Burkitt’s leukemia.
Associated with LACTIC ACIDOSIS & DEFECTIVE CMI.

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