Retained dead fetus
Amniotic fluid embolism
Rocky Mountain spotted fever
Carcinomas of pancreas, prostate, lung, and stomach
Acute promyelocytic leukemia
Massive Tissue Injury
Acute intravascular hemolysis, snakebite, giant hemangioma, shock, heat stroke, vasculitis, aortic aneurysm, liver disease
1)Acute DIC – mainly presents as a bleeding diathesis. shock, with acute renal failure, dyspnea, cyanosis, convulsions, and coma. Hypotension is characteristic. petechiae and ecchymoses on the skin. severe hemorrhage into the gut or urinary tract.
Waterhouse-Friderichsen syndrome – microthrombi in glomeruli may lead to microinfarct in renal cortex – in severe cases can cause renal cortical necrosis, and involvement of adrenal glands in severe cases is known as WF syndrome.
Microinfarcts in the brain may give rise to bizarre neurologic signs.
2) Chronic DIC - tends to present as thrombotic complications.
PT and PTT – prolonged
Fibrin split products are increased in the plasma.