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Minimal-Change Disease (Lipoid Nephrosis) .

characterized by glomeruli that have a normal appearance by light microscopy but show diffuse effacement of podocyte foot processes when viewed with the electron microscope

Commonest cause of nephrotic syndrome in children

The cells of the proximal convoluted tubules are often heavily laden with protein droplets and lipids, but this is secondary to tubular reabsorption

smaller serum proteins, chiefly albumin are excreted in urine (selective proteinuria)

More than 90% of cases respond to a short course of corticosteroid therapy; however, proteinuria recurs in more than two-thirds of the initial responders, some of whom become steroid dependent


Ultrastructural characteristics of minimal change disease: effacement of foot processes (double arrows), absence of deposits, vacuoles (V), and microvilli in visceral
epithelial cells.