Systemic vasculitis affecting medium and small muscular arteries- kidneys 85%, heart 75%, liver 65%, GI 50%
Morphology - acute (fibrinoid necrosis with infiltrate), healed (fibrosis, calcification and infiltrate)
PATHOLOGY: Multiple organs involved, but the lungs are characteristically not involved.
fever, malaise, weakness, leukocytosis and specific organ involvement
Condition is associated with Hepatitis-B in about 30% of cases.
Treatment: steroids, cyclophosphamide