Endomyocardial fibrosis and Endocardial fibroelastosis
Loeffler’s endocarditis – eosinophilic infiltrate due to invasive helminthiasis
Presentation similar to constrictive pericarditis with signs of failure, raised JVP with Kussmaul sign,
Also prone to conduction blocks due to fibrosis
Atrial dilataion due to inadequate ventricular filling
Ventricles are stiff with thick opaque endocardium and valves
Intramural thrombi due to stasis
M/E shows dense fibrosis in endocardial layer
Increased eosinophil infiltration in Loeffler syndrome
Amyloidosis – notice the pink material between the myocytes.
Amyloidosis – Congo Red is very, very positive.
Endomyocardial fibrosis – fibrosis under the endocardium and in the the inner
third of the myocardium.
Endomyocardial fibrosis of a ventricular wall. When extensive, this would cause
restrictive heart failure too.