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Proto-oncogenes (tumor promoters) versus Anti-oncogenes (tumor suppressors)

Abnormal growth of neoplastic cells can arise secondary to mutation of either proto-oncogenes or anti oncogenes. Proto-oncogenes stimulate cell proliferation. Overexpression or amplification of a proto-oncogene leads to increased cellular proliferation and neoplastic growth. Anti-oncogenes, in contrast, are tumor suppressors in that they inhibit cellular proliferation. Inactivation of anti-oncogenes contributes to tumor development.