Friday, December 4, 2015

List of Granulomatous diseases


  • Bartonella henselae(cat scratch disease)
  • Berylliosis
  • Churg-Strauss syndrome
  • Crohn disease
  • Francisella tularensis
  • Fungal infections (e.g., histoplasmosis, 
  • blastomycosis)
  • Granulomatosis with polyangiitis (Wegener)
  • Listeria monocytogenes(granulomatosis 
  • infantiseptica)
  • M. leprae(leprosy; Hansen disease)
  • M. tuberculosis
  • Treponema pallidum(tertiary syphilis)
  • Sarcoidosis 
  • Schistosomiasis

Th1cells secrete ╬│-interferon, activating macrophages. TNF-╬▒from macrophages 
induce and maintain granuloma formation. Anti-TNF drugs can, as a side effect, cause 
sequestering granulomas to breakdown, leading to disseminated disease. Always test for 
latent TB before starting anti-TNF therapy.

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